Datelliptium chloride

CAS No. 105118-14-7

Datelliptium chloride( —— )

Catalog No. M20891 CAS No. 105118-14-7

Datelliptium chloride is a DNA-intercalating agent derived from ellipticine. with anti-tumor activities.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Datelliptium chloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Datelliptium chloride is a DNA-intercalating agent derived from ellipticine. with anti-tumor activities.
  • Description
    Datelliptium chloride is a DNA-intercalating agent derived from ellipticine. with anti-tumor activities.
  • In Vitro
    Datelliptium (100 μM) shows significantly cytotoxic effects after 2 hr of treatment in suspension and primary cultures of rat hepatocytes. Datelliptium mobilizes glycogen in both rat systems in vitro concentration dependently. The half-maximal effect is 14.3 μM in isolated hepatocytes, whereas in cultured rat hepatocytes it is 5.9 μM. Datelliptium also leads to a concentration-dependent decrease in gluconeogenesis from lactate in cells. Datelliptium acetate is selectively cytotoxic for solid tumors over leukemia L1210. Human tumors H-125 and HCT-116 demonstrates less sensitivity to datelliptium acetate.
  • In Vivo
    Upon intravenous administration, datelliptium acetate shows potent inhibitory activities in vivo against a variety of murine solid tumors. Datelliptium acetate is highly active against early-stage colon #38 with highest non-toxic dose (HNTD) of 170 mg/kg TD, and weight loss of 10%, T/C of 0%.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    DNA synthesis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    105118-14-7
  • Formula Weight
    397.94
  • Molecular Formula
    C23H28ClN3O
  • Purity
    >98% (HPLC)
  • Solubility
    H2O:41.67 mg/mL (104.71 mM; Need ultrasonic)
  • SMILES
    CCN(CC)CC[n+]1ccc2c(C)c3[nH]c4ccc(O)cc4c3c(C)c2c1.[Cl-]
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Mucci-Lorusso P Polin L Biernat L A et al. Activity of datelliptium acetate (NSC 311152; SR 95156A) against solid tumors of mice[J]. Investigational New Drugs 1990 8(3):253-261.
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